RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 3 : Photodynamic therapy of cutaneous metastases from breast cancer

Photodynamic therapy of cutaneous metastases from breast cancer

«Radiation and Risk», 2014, vol. 23, No. 3, pp.34-42

Authors

Goranskaya E.V. – Researcher, Oncologist, Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (484) 399-31-46; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kaplan M.A. – Head of Dep., MD, Prof, Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia.

Abstract

Introduction: In 20% of cases the breast cancer is accompanied by the development of cutaneous metastases, which are like dense small round nodules and most commonly present on the chest wall. The purpose of the study was to research into the possibility to use photodynamic therapy (PDT) with the photosensitizer "photolon" for treatment of cutaneous metastases of breast cancer. Materials and methods: PDT with Photolon photosensitizer was administered to 41 patients with skin metastases from breast cancer. The total number of treated nodule and nodular lesions was 392. The photosensitizer at dose of 0.9-1.6 mg/kg was injected to all patients. Radiation area varied from 1 to 6 cm, the number of fields varied from 1 to 26, the light energy density varied from 0.11 to 0.56 J/cm2, a light power density varied from 0.3 to 2.0 W/cm2. Results: Metastases that received PDT showed complete regression in 46% of lesions, partial regression in 39% of lesions, progression occurred in 15%. Objective response to treatment was 85%. Conclusions: The use of PDT with photosensitizers for cutaneous metastases from breast cancer allows obtaining satisfactory results in the presence of insignificant number of side effects.

Key words
Breast cancer, skin metastasis, photosensitizer, chlorine, photolon, laser radiation, photodynamic therapy, fluorescent spectroscopy.

References

1. Gehl J., Matthiessen L.M., Humphreys A. Management of cutaneous metastases by electrochemotherapy. J. Clin. Oncol., 2010, vol. 28, pp. 15.

2. Zolotkov A.G., Aminov G.G., Ragulin Yu.A., Gulidov I.A., Orkina A.B. Sravnitel'nyi analiz rezul'tatov kompleksnogo lecheniya mestnorasprostranennogo raka molochnoi zhelezy s ispol'zovaniem uskorennogo i konvekcial'nogo rezhimov [Comparative analysis of accelerated and conventional radiotherapy regimens in complex treatment of locally advanced breast cancer]. Sibirskiy onkologicheskiy zhurnal – Siberian Journal of Oncology, 2013, no. 3, pp. 20-24.

3. Tsyb A.F., Kaplan M.A., Romanko Yu.S., Popuchiev V.V. Fotodinamicheskaya terapiya [Photodynamic therapy]. Moscow, MIA Publ., 2009. 195 p.

4. Kaplan M.A., Kapinus V.N., Popuchiev V.V., Romanko Yu.S., Yaroslavtseva-Isaeva E.V., Spichenkova I.S., Shubina A.M., Borgul' O.V., Goranskaia E.V. Fotodinamicheskaya terapiya: rezul'taty i perspektivy [Photodynamic therapy: results and prospects]. Radiatsiya i risk – Radiation and Risk, 2013, vol. 22, no. 3, pp. 115-123.

5. Kaplan M.A., Romanko Yu.S. Fotodinamicheskaya terapiya [Photodynamic Therapy]. Fizioterapiea, bal'neologiya i reabilitatsiya – Physiotherapy, Balneology and Rehabilitation, 2004, no. 1, pp. 43-48.

6. Molochkov V.A., Snarskaia E.S., Poliakov P.Yu., Afonin A.V., Suhova T.E., Romanko Yu.S., Hlebnikova A.N., Taranec T.A., Koroleva L.P., Kladova A.Yu., Chelyukanova M.V., Kozlova E.S. K probleme lecheniia bazaliom kozhi [To the problem of treatment of skin basalioma]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney – Russian Journal of cutaneous and venereal diseases, 2005, no. 6, pp. 4-9.

7. Romanko Yu.S., Kaplan M.A., Popuchiev V.V., Molochkov V.A., Sukhova T.E., Tret'iakova B.I., Taranets T.A. Bazal'no-kletochnyy rak kozhi: problemy lecheniya i sovremennye aspekty fotodinamicheskoi terapii [Skin basal cell carcinoma: problems of treatment and modern aspects of photodynamic therapy]. Rossi-iskiy zhurnal kozhnykh i venericheskikh boleznei – Russian Journal of cutaneous and venereal diseases, 2004, vol. 6, pp. 6-10.

8. Romanko Yu.S., Kaplan M.A., Popuchiev V.V., Surova L.V., Epatova T.V. Photodynamic therapy for rheumatoid arthritis. Radiation and Risk, 2014, vol. 23, no. 1, pp. 66-77. [in Russian]. 9. Tsyb A.F., Kaplan M.A., Romanko Yu.S., Popuchiev V.V. Klinicheskie aspekty fotodinamicheskoy terapii [Clinical aspects of photodynamic therapy]. Kaluga, Izdatel'stvo nauchnoy literatury N.F. Bochkarevoy Publ., 2009. 204 p.

10. Kaplan M.A., Nikitina R.G., Romanko Yu.S., Bozadzhiev L.L., Malygina A.I. Fotodinamicheskaya terapiya sarkomy M-1 u eksperimental'nykh zhivotnykh [Photodynamic therapy for sarcoma M-1 in animal models]. Lazernaya meditsina – Laser Medicine, 1998, vol. 2, no. 2-3, pp. 38-42.

11. Kaplan M.A., Ponomarev G.V., Baum R.F., Romanko Yu.S., Mardynskaia V.P., Malygina A.I. Izuchenie spetsificheskoy fotodinamicheskoy aktivnosti fotoditazina pri fotodinamicheskoy terapii sarkomy M-1 u krys [Study of specific activity of photoditazine for photodynamic therapy of sarcoma M-1 in rats]. Rossiyskiy bioterapevticheskiy zhurnal – Russian Biotherapeutical Journal, 2003, vol. 2, no. 4, pp. 23-30.

12. Romanko Yu.S., Korenev S.V., Popuchiev V.V., Vaisbein I.Z., Sukhova T.E. Osnovy fotodinamicheskoy terapii [Basics of photodynamic therapy]. Kaliningrad, Strazh Baltiki Publ., 2010. 136 p.

13. Romanko Yu.S., Tsyb A.F., Kaplan M.A., Popuchiev V.V. Effect of photodynamic therapy with photoditha-zine on morphofunctional parameters of M-1 sarcoma. Bulletin of Experimental Biology and Medicine, 2004, vol. 138, no. 6, pp. 584-589.

14. Romanko Yu.S., Tsyb A.F., Kaplan M.A., Popuchiev V.V. Relationship between antitumor efficiency of photodynamic therapy with photoditasine and photoenergy density. Bulletin of Experimental Biology and Medicine, 2005, vol. 139, no. 4, pp. 460-464.

15. Dougherty T.J. An update on photodynamic therapy applications. J. Clin. Laser. Med. Surg., 2002, vol. 20, no. 1, pp. 3-7.

16. Huang Z., Xu H., Meyers A., Musani A., Wang L., Tagg R., Bardawi A., Chen Y. Photodynamic therapy for treatment of solid tumors-potential and technical challenges. Technol. Cancer. Res. Treat., 2008, vol. 7, no. 4, pp. 309-320.

17. Skugareva O.A., Popuchiev V.V., Sukhova T.E., Kapinus V.N., Kaplan M.A. Fotodinamicheskaya terapiya s interstitsial'nym oblucheniem opukholi [Interstitial Photodynamic therapy]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney – The Russian Journal of cutaneous and venereal diseases, 2012, vol. 2, pp. 4-6.

18. Kaplan M.A., Romanko Yu.S., Popuchiev V.V., Yuzhakov V.V., Bandurko L.N., Mihina L.N., Fomina I.K., Malygina A.I., Ingel' I.E. Vliyanie plotnosti svetovoi energii na protivoopukholevuyu effektivnost' foto-dinamicheskoi terapii s fotoditazinom [Influence of light energy density at antineoplastic efficiency of photodynamic therapy with photoditazin]. Lazernaya meditsina – Laser Medicine, 2005, vol. 9, no. 2, pp. 46-54.

19. Kaplan M.A., Romanko Yu.S., Popuchiev V.V., Yuzhakov V.V., Bandurko L.N., Fomina N.K., Mihina L.N., Malygina A.I., Ingel' I.E. Deistvie fotodinamicheskoi terapii na rost i funktsional'nuyu morfologiyu sarkomy M-1 [Action of photodynamic therapy with photoditazin on growth and functional morphology of sarcoma M-1]. Lazernaya meditsina – Laser Medicine, 2005, vol. 9, no. 4, pp. 41-47.

20. Castano A.P., Mroz P., Hamblin M.R. Photodynamic therapy and antitumour immunity. Nature Reviews Cancer, 2006, vol. 6, pp. 535-545.

21. Romanko Yu.S. Fotodinamicheskaia terapiia bazal'no-kletochnogo raka kozhi (eksperimental'no-klinicheskoe issledovanie). Avtoref. diss. dokt. med. nauk. [Photodynamic therapy for squamous cell carci-noma of the skin (experimental and clinical study). Dr. med. sci. diss. synopsis]. Obninsk, 2005. 41 p.

22. WHO Handbook for Reporting Results for Cancer Treatment. Geneva, WHO, 1979, рр. 24-25.

23. Vakulovskaya E.G., Shental' V.V. Fotodinamicheskaya terapiya i flyuorestsentnaya diagnostika u bol'nykh rakom molochnoy zhelezy s ispol'zovaniem otechestvennykh fotosensibilizatorov [Photodynamic therapy and fluorescence diagnostics of breast cancer using domestic photosensitizers]. Lazernaya meditsina – Laser medicine, 2002, vol. 6, no. 1, pp. 25-28.

24. Cuenca R.E., Allison R.R., Sibata C., Downie G.H. Breast cancer with chest wall progression: treatment with photodynamic therapy. Annals of Surgical Oncology, 2004, vol. 11, no. 3, pp. 322-327.

25. Wyss P., Schwarz V., Dobler-Girdziunaite D., Hornung R., Walt H., Degen A., Fehr M. Photodynamic therapy of locoregional breast cancer recurrences using a chlorin-type photosensitizer. Int. J. Cancer, 2001, vol. 93, pp. 720-724.

Full-text article (in Russian)