Estimating of radiation risks of malignant neoplasms among Russian Chernobyl cleanup workers

«Radiation and Risk», 2021, vol. 30, No. 1, pp.58-77

DOI: 10.21870/0131-3878-2021-30-1-58-77

Authors

Kashcheev V.V. – Head of Lab., C. Sc., Biol.
Chekin S.Yu. – Head of Lab. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249035. Tel.: (484) 399-30-79; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Karpenko S.V. – Engineer
Maksioutov M.A. – Head of Dep., C. Sc., Tech.
Tumanov K.А. – Head of Lab., C. Sc., Biol.
Kochergina E.V. – Head of Lab., C. Sc., Med.
Glebova S.E. – Lead. Researcher, C. Sc., Med.
Ivanov S.A. – Director, MD, Prof. A. Tsyb MRRC.
Kaprin A.D. – General Director, Academician of RAS, MD, Prof. NMRRC.
A. Tsyb MRRC, Obninsk
¹ NMRRC Russian Ministry of Health, Moscow

Abstract

The paper considers radiation risks of solid cancer incidence and mortality, as well as risk of leukemia incidence (other than chronic lymphocytic leukemia) among Russian Chernobyl cleanup workers (liquidators). The study of the cohort of liquidators carried out at the National Radiation Epidemiological Registry (NRER) was based on the follow-up data collected from 1992 over 2019. The size of the Chernobyl cleanup workers cohort exceeded 65 thousand people, their average age at the time of entering the exclusion zone was 34 years, the average external gamma radiation dose received by liquidators during their cleanup work was about 0.133 Gy. Radiation-induced risks of solid cancer incidence and mortality in the study cohort were statistically significant, the risk magnitude rose with increasing the follow-up length. For the maximum follow-up period, from 1992 over 2019, the excess relative risk coefficient for solid cancer incidence was ERR/Gy=0.62, 95% CI (0.29; 0.98), and excess relative risk coefficient for solid cancer mortality was ERR/Gy=0.74, 95% CI (0.32; 1.22), the estimated coefficients were in good agreement with similar coefficients calculated for the Russian liquidators with the use of ICRP radiation risk models. Non-parametric estimates of relative radiation risk within the same dose intervals for solid cancers and for leukemias in the cohort of liquidators were statistically significant for radiation doses above 0.150 Gy. For radiation doses below 0,150 Гр the linear non-threshold model is conservative, i.e. there was evidence for statistically significant radiation risk of leukemia incidence among liquidators during the first 11 years after the accident, from 1986 over 1997, ERR/Gy=4.41, 95% CI (0.24; 14.23). In later years, until 2018 there was no evidence of radiation-related risk of leukemia incidence. Outcomes of future studies will impact on optimization of radiological protection, development of reference levels for Russian general public exposure and improvement of the system for delivery of targeted medical care to people exposed to radiation.

Key words
cohort studies, morbidity, mortality, solid malignant neoplasms, leukemia, cohort of liquidators, observation period, excess relative risk, standardized incidence ratio, standardized mortality ratio, nonparametric estimates of radiation risk, radiation risk, radiation dose.

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