Issues
Updated results of the radiation epidemiological study of the incidence of the descendants of the first generation of participants in the consequences of the Chernobyl accident
«Radiation and Risk», 2026, vol. 35, No. 2, pp.128-139
DOI: 10.21870/0131-3878-2026-35-2-128-139
Authors
Korelo A.M. – Sen. Researcher. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249035; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .Chekin S.Yu. – Head of Lab.
Tumanov K.A. – Head of Lab., C. Sc., Biol.
Karpenko C.V. – Engineer
Zelenskaya N.S. – Researcher
Lashkova O.E. – Researcher
Shchukina N.V. – Sen. Researcher
Maksioutov M.A. – Head of Dep., C. Sc., Tech. A. Tsyb MRRC.
A. Tsyb MRRC, Obninsk
Abstract
When protecting and managing populations exposed to ionizing radiation, special attention is paid to the problem of proving hereditary risks of radiation-induced morbidity in humans. The study of the morbidity of the descendants of the first generation of participants in the consequences of the Cher-nobyl accident was carried out using data accumulated in the National Radiological and Epidemio-logical Registry over 38 years of observation of a cohort consisting of 15,450 descendants. The pre-vious analysis of data on the health status of participants in the offspring cohort was conducted five years ago. Parametric modeling of morbidity did not reveal an association between the radiation dose of fathers and the prevalence of congenital diseases of their offspring. The age of the father at the time of conception was a statistically significant factor – the congenital morbidity was higher in off-spring whose fathers were over 30 years old. The age of the father, his exposure, and the time elapsed from the father's exposure to the birth of the child did not affect the cancer incidence of the offspring. For most classes of non-cancerous diseases, no statistically significant dependence on the dose of the father's radiation was found, but a relationship with age and time elapsed after irradiation was revealed. At the end of the study, the cohort members were under 40 years old. Continued monitoring of their health status may lead to stable estimates of radiation risk for individual diseases.
Key words
National Radiation and Epidemiological Registry, Chernobyl liquidators, descendants of irradiated parents, congenital malformations, radiation dose, radiation and epidemiological analysis, impact of radiation exposure on the morbidity of offspring, assessment of radiation risk, public health.
References
1. Sosnina S.F., Sokolnikov M.E. Heritable effects in offspring associated with harmful exposure to parents (Literature review). Radiatsionnaya gygiena – Radiation Hygiene, 2019, vol. 12, no. 3, pp. 84-95. (In Russian).
2. Stephens J., Moorhouse A.J., Craenen K., Schroeder E., Drenos F., Anderson R. A systematic review of human evidence for the intergenerational effects of exposure to ionizing radiation. Int. J. Radiat. Biol., 2024, vol. 100, no. 9, pp. 1330-1363.
3. Amrenova A., Baudin C., Ostroumova E., Stephens J., Anderson R., Laurier D. Intergenerational effects of ionizing radiation: review of recent studies from human data (2018-2021). Int. J. Radiat. Biol., 2024, vol. 100, no. 9, pp. 1253-1263.
4. Panchenko A.V., Popovich I.G., Fedoros E.I., Pigarev S.E. Carcinogenic risk in the offspring of preconcep-tionally irradiated mammals: a systematic review. Voprosy onkologii – Problems in Oncology, 2025, vol. 71, no. 2, pp. 256-268. (In Russian).
5. Kochergina E.V., Gorski A.I., Chekin S.Yu., Korelo A.M., Tumanov K.A., Zelenskaya N.S., Shchukina N.V., Karpenko S.V., Maksioutov M.A. General morbidity among children of Chernobyl cleanup workers: radiation epidemiological study. Radiatsiya i risk – Radiation and Risk, 2021, vol. 30, no. 1, pp. 110-130. (In Russian).
6. Ivanov V.K., Maksioutov M.A., Tumanov K.A., Kochergina E.V., Vlasov O.K., Chekin S.Yu., Gorski A.I., Korelo A.M., Shchukina N.V., Zelenskaya N.S., Lashkova O.E., Ivanov S.A., Kaprin A.D. 35-year experi-ence in the functioning of the National Radiation and Epidemiological Registry as a State information system for monitoring the radiological consequences of the Chernobyl accident. Radiatsiya i risk – Radiation and Risk, 2021, vol. 30, no. 1, pp. 7-39. (In Russian).
7. International Statistical Classification of Diseases and Related Health, 10th revision (ICD-10). Vol. 1 (Part 1). Geneva, WHO, 1995. 698 p. (In Russian). /p>
8. Lumley T., Kronmal R., Ma Sh. Relative risk regression in medical research: models, contrasts, estimators, and algorithms. Biostatistics Working Paper Series. Seattle, WA, University of Washington, 2006. Available at: http://biostats.bepress.com/uwbiostat/paper293 (Accessed 15.01.2026).
9. R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Com-puting. Vienna, Austria. Available at: https://www.R-project.org/ (Accessed 15.01.2026).
10. Turner H., Firth D. Generalized nonlinear models in R: an overview of the gnm package (R package version 1.1-5). Available at: https://CRAN.R-project.org/package=gnm (Accessed 15.01.2026).
11. Barrett T., Dowle M., Srinivasan A., Gorecki J., Chirico M., Hocking T., Schwendinger B., Krylov I. 2025 data.table: extension of ‘data.frame’ (R package version 1.17.99). Available at: https://r-datatable.com (Accessed 15.01.2026).
12. Yamada M., Furukawa K., Tatsukawa Y., Marumo K., Funamoto S., Sakata R., Ozasa K., Cullings H.M., Preston D.L., Kurttio P. Congenital malformations and perinatal deaths among the children of atomic bomb survivors: a reappraisal. Am. J. Epidemiol., 2021, vol. 190, no. 11, pp. 2323-2333.
13. Gardner M.J., Snee M.P., Hall A.J., Powell C.A., Downes S., Terrell J.D. Results of case-control study of leukemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ, 1990, vol. 300, no. 6722, pp. 423-429.
14. Yoshimoto Y., Neel J.V., Schull W.J., Kato H., Soda M., Eto R., Mabuchi K. Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. Am. J. Hum. Genet., 1990, vol. 46, no. 6, pp. 1041-1052.
15. Grant E.J., Furukawa K., Sakata R., Sugiyama H., Sadakane A., Takahashi I., Utada M., Shimizu Y., Ozasa K. Risk of death among children of atomic bomb survivors after 62 years of follow-up: a cohort study. Lancet Oncol., 2015, vol. 16, no. 13, pp. 1316-1323.
16. Sosnina S.F., Okatenko P.V., Denisova E.V., Sokolnikov M.E. Risk of central nervous system tumors in the offspring of individuals exposed to production radiation. Fundamentalnaya i klinicheskaya meditsina – Fundamental and Clinical Medicine, 2024, vol. 9, no. 3, pp. 8-18. (In Russian).
17. Tatsukawa Y., Cologne J.B., Hsu W.L., Yamada M., Ohishi W., Hida A., Furukawa K., Takahashi N., Nakamura N., Suyama A., Ozasa K, Akahoshi M, Fujiwara S, Shore R. Radiation risk of individual multi-factorial diseases in offspring of the atomic-bomb survivors: a clinical health study. J. Radiol. Prot., 2013, vol. 33, no. 2, pp. 281-293.
18. Sosnina S.F., Okatenko P.O., Sokolnikov M.E. Consequences of parental preconceptional irradiation: en-docrine-metabolic pathology in offspring. Radiatsionnaya gygiena – Radiation Hygiene, 2022, vol. 15, no. 4, pp. 15-33. (In Russian).
19. Brent R.L. Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors. Pediatrics, 2004, vol. 113, no. 4(Suppl.), pp. 957-968.
