Effect of irradiation of male rats on the development of posterities of two generations spermatides

«Radiation and Risk», 2011, vol. 20, no. 1, pp.19-23

Authors

Palyga G.F. – Main Res., MD, Prof. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-70-45; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Chibisova O.F. – Res. Assistant. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk
Ivanov V.L. – Sen. Res., C. Sc., Vet. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk
Dergilev A.A. – Postgraduate Student. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk
Zhavoronkov L.P. – Head of Lab., MD. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk
Panfilova V.V. – Postgraduate Student. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk
Kolganova O.I. – Senior Researcher. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk

Abstract

Study of antenatal and postnatal development of two generations of posterity of male Wistar rats which spermatides were gama-irradiated (60Co) with doses below those causing sexual sterility (0.5-1.5 Gy, dose rate 0.003 Gy/s) is presented. The greatest changes are found at embryonic growth of posterity of both generations. This means that gama-radiation causes genomic instability.

Key words
Wistar rats, males, irradiation of spermatides, posterity.

References

1. Dubrova Yu.E. The instability of the genome among descendants of irradiated parents. The facts and their interpretation. Genetics. 2006. Vol. 42, no. 10. PP. 1-10.

2. Palyga G.F., Zakoschikov K.F., Epatova Т.V. Influence of total gamma irradiation of females on pregnancy and postnatal development of offspring. Archive of anatomy, histology and embryology. 1984. Vol. LXXXVII, no. 12. PP.71-76.

3. Palyga G.F., Chibisova OF, Ivanov V.L. and others. The implementation of radiation effects in ontogeny of the offspring of two generations of males whose sexual cells are irradiated once in non-sterilizing doses at the stage of mature spermatozoa. Radiation and Risk. 2010. Vol. 19, no. 4. PP. 58-62.

4. Clermont Y., Leblond C., Messier B. Dures du cycle de l'epithehelium seminaliandu Raat. Archiv anat., microsc., morphol. exp. 1959. Vol. 48. PP. 37-56.

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