Diagnosis and treatment of medullary thyroid cancer

«Radiation and Risk», 2013, vol. 22, No. 3, pp.106-114

Authors

Isaev P.A. – Lead. Researcher, MD, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Ilyin А.А. – Lead. Researcher, MD, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Medvedev V.S. – Head of Dep., MD, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Siomin D.Yu. – Physician, Cand. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Polkin V.V. – Senior Res., Cand. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Derbugov D.N. – Physician, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Vasilkov S.V. – Researcher, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-32-01; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Chebotareva I.V. – Physician., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.

Abstract

Outcome of treatment for medullary thyroid carcinoma in 85 patients aged 7-78 years is discussed. Analysis of ten-year relapse-free survival shows that such factors as distant metastases and metastases to lymph nodes, extrathyroidal invasion of the tumor negatively affect survival (р<0.01), and presence of encapsulated tumor and extended surgical treatment favorably affect survival (р<0.05). Telegamma therapy does not significantly affect tumor regression. Poor prognostic factors of treatment outcome are: age of patients (older than 50 years), extrathyroidal ivasion of the tumor, regional metastases and high level of thyrocalcitonin (TCT) in blood serum.

Key words
Мedullary thyroid cancer, diagnosis, treatment.

References

1. Brzhezovskii V.Zh., Liubaev V.L. Diagnostika i lechenie medulliarnogo raka shchitovidnoi zhelezy. Prakticheskaia onkologiia, 2007, vol. 8, no. 1, pp. 29-35.

2. Demidchik Iu.E., Kolbukhov A.E., Demidchik Z.E. i dr. Rezul'taty lecheniia bol'nykh medulliarnym rakom shchitovidnoi zhelezy u detei. Onkologicheskii zhurnal, 2008, no. 3, pp. 44-47.

3. Il'in A.A., Rumiantsev P.O. Diagnostika i lechenie semeinykh form medulliarnogo raka shchitovidnoi zhelezy. Problemy endokrinologii, 2000, no. 4, pp. 19-22.

4. Blom C.B., Ceolin L., Romitti M. et al. The rare intracellular RET mutation p.Ser891Ala in an apparently sporadic medullary thyroid carcinoma: a case report and review of the literature. Arq. Bras. Endocrinol. Metabol., 2012, vol. 56, pp. 586-591.

5. Brierley J., Sherman E. The role of external beam radiation and targeted therapy in thyroid cancer. Semin. Radiat. Oncol., 2012, vol. 22, pp. 254-262.

6. La Rosa S., Imperatori A., Giovanella L. et al. Thyroid metastases from typical carcinoid of the lung differentiating between medullary thyroid carcinoma and neuroendocrine tumor metastasis to the thyroid. Thyroid., 2009, vol. 19, pp. 521-526.

7. Mazeh H., Sippel R.S. Surgical management of medullary thyroid cancer. Minerva Endocrinol., 2012, vol. 37, pp. 329-334.

8. Oshiro C., Kamigaki S., Arai T. et al. A case of thyroid medullary carcinoma with multiple painful bone metastases successfully treated with strontium-89 chloride. Gan To Kagaku Ryoho., 2012, vol. 39, pp. 951-953.

9. Trimboli P., Nasrollah N., Amendola S. et al. Should we use ultrasound features associated with papillary thyroid cancer in diagnosing medullary thyroid cancer? Endocr. J., 2012, vol. 30, pp. 503-508.

Full-text article (in Russian)