RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 2 : Efficiency of photodynamic therapy with intralesional photosensitizer for skin basal-cell carcinoma

Efficiency of photodynamic therapy with intralesional photosensitizer for skin basal-cell carcinoma

«Radiation and Risk», 2014, vol. 23, No. 2, pp.37-44

Authors

Matveeva O.V.1 – Assistant Prof., C. Sc., Med., Sechenov First Moscow State Medical University. Contacts: 8/2 Trubetskaya St., Moscow, Russia, 119991. Tel.: +79262062443; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Sukhova T.E.2 – Senior Researcher, MD, Vladimirskii Moscow Oblast Clinical and Research Institute.

Abstract

The purpose of the study is to estimate efficiency of photodynamic therapy (PDT) with intralesional photosensitizer Radachlorine for different clinical types and histological forms of skin basal-cell carcinoma (BCC). Photodynamic therapy with intralesional photosensitizer Radachlorine was used to treat primary and recurrent clinical forms of Т1-2N0M0 BCC with solitary and multiple lesions of different histological types. We estimated efficiency of primary treatment outcome using clinical and histological data in 3 months, secondary outcome – in 12 months after the treatment. Delayed disease-free period was estimated annually during 5 years. Difference between early and delayed treatment outcomes regardless clinical and histological forms of the disease was not significant. In five years after the treatment disease free status was in 97,7% of patients under study, a recurrence of the disease was found in 1 patient (2,3%) with primary stage Т2N0M0, ulcer-like lesion of solid adenoid histological type on the nose wing. Results of the study allow us to conclude that photodynamic therapy with intralesional photosensitizer Radachlorine is effective treatment modality for all forms and histological types of skin basal-cell carcinoma. We recommend that the study of medical application of PDT be continued.

Key words
Basal-cell carcinoma, photodynamic therapy, intralesional photosensitizer, «Radachlorin», laser radiation, local tumor irradiation, selective treatment of tumor.

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