RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 2 : Late response of gastric endocrine cells to gamma-radiation

Late response of gastric endocrine cells to gamma-radiation

«Radiation and Risk», 2014, vol. 23, No. 2, pp.95-101

Authors

Popuchiev V.V.1 – Lead. Researcher, MD., Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: +7 (48439) 9-12-32; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Konoplyannikov A.G.1 – Head of Dep., D. Sc., Biol., Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk.
Safinova L.Sh.2 – Assistant Prof., C. Sc., Med., Bashkir State Medical University, Ufa, Russia.

Abstract

Quantitative immunohistochemical methods were used for analysis of gastric endocrine cells following whole-body γ-irradiation of white rats. Inhibition of steroidogenesis with metopirone, was found to reduce radiation damages to the cells. We suppose that this effect is associated with reduced influence of stress hormones on population of resident stem cells.

Key words
Radiation, γ-irradiation, endocrine cells, steroidogenesis, metopirone, stomach, stem cells, stress, immunohistochemistry.

References

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Full-text article (in Russian)