RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2015 : vol. 24, No. 4 : Efficiency of thermoradiation therapy in combined treatment of locally advanced laryngeal and hypopharyngeal cancers

Efficiency of thermoradiation therapy in combined treatment of locally advanced laryngeal and hypopharyngeal cancers

«Radiation and Risk», 2015, vol. 24, No. 4, pp.74-86

Authors

Spivakova I.O.1 – Postgraduat Student. Tomsk Cancer Research Institute, Russia. Contacts: 12/1 Savinykh str., Tomsk, Russia, 634028. Tel.: +7 (3822) 41-80-62; е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Choynzonov E.L.1,2 – Director, MD, Academician of RAS. Tomsk Cancer Research Institute, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Mukhamedov M.R.1,2 – Lead. Researcher, MD. Tomsk Cancer Research Institute, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Startseva Zh.A.1 – Head of Dep., MD. Tomsk Cancer Research Institute, Russia.
Vasilyev N.V.1 – Senior Researcher, C. Sc., Med. Tomsk Cancer Research Institute, Russia.
Gribova O.V.1 – Res. Assistant, C. Sc., Med. Tomsk Cancer Research Institute, Russia.

Abstract

The article presents results of combined treatment of locally advanced laryngeal and hypopharyn-eal cancers, stages III-IV (Т3N0-2M0). All patients (55) were divided into 2 groups. The patients of the group 1 (25 people) were given pre-operative thermoradiation therapy, the patients of the group 2 (30 people) were given pre-operative radiation therapy only. The follow-up period lasted 6-24 months. After pre-operative treatment partial tumor regression and growth stabilization were diagnosed in 21 (84%) and 4 (16%) patients of the group 1 respectively. In the group 2 partial tumor regression and growth stabilization were diagnosed in 18 (60%) and 12 (49%) patients respectively. Local and regional recurrences were developed in 1 patient (4%) of the group 1 in the first year of follow-up and in 11 patients of the group 2, among them 7 recurrences were diagnosed in the first year and 4 – in the second year of the follow-up. Two-year overall survival was 100% in the group 1 and 76.7±10.1% – in the group 2. Disease-free survival was 96.6±.5% and 63.3±13.9% respectively.

Key words
laryngeal cancer, hypopharyngeal cancer, neoadjuvant radiation therapy, thermoradiation therapy, organ-sparing operations, therapeutic pathomorphosis, treatment efficiency, survival, recurrences, combined treatment.

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