Effect of low-intensity radiation on the morphological features of Peyer's plaque

«Radiation and Risk», 2021, vol. 30, No. 4, pp.108-116

DOI: 10.21870/0131-3878-2021-30-4-108-116

Authors

Vasyanina K.A. – Senior Lecturer, C. Sc. Med. Contacts: 21/28 3rd Bogatyrskaya str., Moscow, Russia, 107564. Tel.: 8-977-643-71-77; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Klyueva L.A. – Assoc. Prof., C. Sc. Med.
Shemyakov S.E. – Head of Dep., MD, Prof. N.I. Pirogov RNRMU.
Olsufieva A.V. – Head of Dep., C. Sc. Med. Synergy University.
Zotkin D.A. – Senior Lecturer
Vovkogon A.D. – Assoc. Prof., C. Sc. Med.
Timofeeva M.O. – Senior Lecturer
Kudryavtsev-Rashevsky D.V. – Student of N.V. Sklifosovsky ICM. I.M. Sechenov First MSMU.
Kosyreva A.M. – Lead. Researcher, D. Sc. Biol. RIHM.
¹ N.I. Pirogov RNRMU, Moscow
² Synergy University, Moscow
³ I.M. Sechenov First MSMU, Moscow
⁴ RIHM, Moscow

Abstract

Radiation has a negative impact on human health because of its high penetrating power. Mitotically dividing cells and the lymphoid tissue of the gastrointestinal tract are most radiosensitive. The intestine is the major zone of sensitization and recycling of immunocytes that populate the mucous membranes of other organs. Immune-competent tissues of the digestive tract are represented by lymphoid tissue, where the leading role belongs to Peyer's plaques-group accumulations of lymphoid tissue. The antigen-sensitized lymphocytes of Peyer's plaques migrate to the mesenteric lymph nodes, and from there through the lymphatic vessels through the thoracic duct and circulatory system and are directed to their own layer of the intestinal mucosa, mainly as IgA-secreting cells. This mechanism ensures the formation of clones of lymphocytes and the formation of specific antibodies in the areas of the mucous membrane that are remote from the focus of primary sensitization. The important thing is that, unlike other lymphoid tissues that require infection or local immunization to form a germinal center, reproduction centers are always present in Peyer's plaques, regardless of the presence of infection.

Key words
low-intensity gamma-radiation, small intestine, Peyer's plaque, irradiation time, lymphoid tissue, exposure dose, immunocompetent cells, germinal centers.

References

1. Zavarykina T.M. Strukturnyye izmeneniya DNK pri deystvii nizkointensivnoy ioniziruyushchey radiatsii v malykh dozakh: Avt. diss. kand. med. nauk [Structural changes in DNA under the action of low-intensity ionizing radiation in low doses. Kand. med. sci. diss]. Moscow, 2008. 26 p.

2. Il’in L.A., Kirillov L.A., Korenkov I.P. Radiation hygiene. Moscow, Geotar-Media, 2010. 384 p. (In Russian).

3. Nichiporuk I.A., Vasil’yeva G.Yu., Rykova M.P., Antropova E.N., Berendeyeva T.A., Belousova I.V. The relationship of the psychoneuroendocrine system and immune status in conditions of short-term hypokinesia and 7-day “dry” immersion. Mechanisms of the functioning of visceral systems: Proc. 7th All-Russ. Conf. Sankt-Petersburg, 2009, pp. 314-315. (In Russian).

4. Morukov B., Rykova M., Antropova E., Berendeeva T., Ponomaryov S., Larina I. T-cell immunity and cytokine production in cosmonauts after long-duration space flights. Acta Astronautica, 2011, vol. 68, no. 7, pp. 739-746.

5. Popova M.F. Radiochuvstvitel’nost’ i stimuliruyushchiye svoystva regeneriruyushchikh tkaney mlekopitayushchikh [Radiosensitivity and stimulating properties of regenerating mammalian tissues]. Moscow, Nauka Publ., 1984. 174 p.

6. Gusarov I.I., Ivanov S.I. Protective effects of low doses of ionizing radiation: a review of the literature. ANRI – ANRI Journal, 2001, no. 4, pp. 8-17. (In Russian).

7. Mazurik V.K., Moroz B.V. Problems of radiobiology and p-53 protein. Radiatsionnaya biologiya. Radioekologiya – Radiation Biology. Radioecology, 2001, vol. 41, no. 5, pp. 548-572. (In Russian).

8. Grigorenko D.E., Erofeeva L.M., Sapin M.R. Cytological profile of the thymus and spleen of mice after gamma irradiation. Morfologiya – Morphology, 1997, vol. 112, no. 6, pp. 53-57. (In Russian).

9. Johnston C.J., Manning С., Hernady Е., Reed C., Thurston S.W., Finkelstein J.N., Williams J.P. Effect of total body irradiation on late lung effects: hidden dangers. Int. J. Radiat. Biol., 2011, vol. 87, no. 8, pp. 902-913.

10. Tatarkin S.V. The hemopoiesis and metabolic status of the erythrocytes of mice with prolonged combined exposure to ionizing radiation and chemicals that simulate the conditions of interplanetary flights: Cand. med. sci. diss. Moscow, 2013. 26 p. (In Russian).

11. Klochkova S.V., Kvaratskheliya A.G., Alekseyeva N.T., Nikityuk D.B. On the rehabilitation possibilities of the lymphoid tissue of the small intestine in mice after the action of a low-intensity radiation factor. Byulleten’ eksperimental’noy biologii i meditsiny – Bulletin of Experimental Biology and Medicine, 2017, vol. 164, no. 8, pp. 245-248. (In Russian).

12. Shafirkin A.V., Kolomenskiy A.V., Mitrikas V.G., Petrov V.M. Dose loads and radiation risk values for astronauts during the expedition to Mars based on the actual design of the Martian spacecraft. Aviakosmicheskaya i ekologicheskaya meditsina – Aerospace and Environmental Medicine, 2010, vol. 44, no. 1, pp. 5-14. (In Russian).

13. Rybkina V.L., Azizova T.V., Mayneke V., Shertan G., Derr H., Adamova G.V., Teplyakova O.V., Osovets S.V., Pikulina M.V., Zurochka A.A. The influence of chronic radiation on some indicators of immunity. Immunologiya – Immunology, 2015, no. 3, pp. 145-149. (In Russian).

14. Buklis Yu.V. Issledovaniye immunnykh struktur selezenki u myshey posle vozdeystviya khronicheskogo radiatsionnogo faktora nizkoy intensivenosti (ekserimental’no-morfologicheskoye issledovaniye). Avt. diss. kand. med. nauk. [Investigation of the immune structures of the spleen in mice after exposure to a chronic radiation factor of low intensity (an eksperimentalno-morphological study: Cand. med. sci. diss. auth ref. Moscow, 2012. 27 p. (In Russian).

15. Grigorenko D.E. Features of the cellular composition of the lymphoid tissue of the spleen of mice after prolonged use of easily isotopic water and irradiation. Morfologiya – Morphology, 2015, vol. 148, no. 4, pp. 19-23. (In Russian).

Full-text article (in Russian)