Features of age-related changes in the skin in people living near uranium tailings in mountains

«Radiation and Risk», 2022, vol. 31, No. 1, pp.29-39

DOI: 10.21870/0131-3878-2022-31-1-29-39

Authors

Isupova А.А. – Associate Prof., C. Sc., Med. KRSU, KSMA. Contacts: 44, Kievskaya str., Bishkek, Kyrgyz Republic, 720000. Tel.: + 7-926-019-06-66; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kyrgyz-Russian Slavic University, Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic

Abstract

The work touches upon the issue of long-term influence (more than 50 years) of low doses of radiation on the condition of the skin. The role of long-term incoming radionuclides into the internal environment of the body on the development of age-related changes in the skin in people living near uranium tailings in mountainous conditions has been studied. 355 indigenous people of Kyrgyzstan were ex-amined. Of these, 62 (17.5%) people were withdrawn from the study according to the exclusion cri-teria. The sample consisted of 293 people. The main group consisted of 75 people, including 45 (60%) women and 30 (40%) men, mean age 38.7+-14.7 (95% CI 35.3-42.1) years. The control group consisted of 218 people, of which 99 (45.4%) were men and 119 (54.6%) were women. Age range from 17 to 77 years. Clinical studies were carried out according to the generally accepted methodology. Differential diagnosis of skin neoplasms was carried out using a Heine Delta 20 dermatoscope (K-256.27.376, Heine Optotechnik, Germany). Statistical analysis was performed using PASW Statistics 21.0 (SPSS Inc., IBM, Chicago, USA). To assess the effect of a risk factor, the attributable risk, risk ratio, and potential harm index (NNT) were calculated, and a 95% confidence interval was calculated for each variable. Statistical analysis of clinical and epidemiological data made it possible to identify a number of geriatric signs to assess the influence of a risk factor on age-related changes in the skin. The additional risk of age-related skin changes varies from 372.82% (95% CI 31.5-42.5%) to 63.2+-2.81 (95% CI 57.7-68.7 %) compared with the control group. The degree of sensitivity of geriatric stigmas to the risk factor is different. At the same time, the relative contribution of the risk factor can be assessed by the severity of the frequency of occurrence of geriatric signs in people living in the zone of radioactive waste disposal in comparison with residents of conditionally "clean" living areas.

Key words
radionuclides, internal irradiation, human skin, skin integuments, stigmas of age-related skin changes, aging of the body, aging of the skin, uranium tailings, skin diseases, diagnostics of skin neoplasms, attributive risk, risk ratio, NNT.

References

1. Ivanov V.K., Korelo A.M., Tumanov K.A., Pryakhin E.A., Panfilov A.P., Raikov S.V. Quantification of the likelihood of radiation-induced diseases due to internal exposure. Radiatsiya i risk – Radiation and Risk, 2013, vol. 22, no. 1, pp. 7-14. (In Russian).

2. Shaki F., Zamani E., Arjmand A., Pourahmad J. A review on toxicodynamics of depleted uranium. Iran. J. Pharm. Res., 2019, vol. 18, no. 1, pp. 90-100.

3. Rolison J.M., Stirling C.H., Middag R., Rijkenberg M.J.A. Uranium stable isotope fractionation in the Black Sea: modern calibration of the 238U/235U paleo-redox proxy. Geochim. Cosmochim. Acta, 2017, vol. 203, pp. 69-88.

4. Miller A.C., Rivas R., Tesoro L., Kovalenko G., Kovaric N., Pavlovic P., Brenner D. Radiation exposure from depleted uranium: the radiation bystander effect. Toxicol. Appl. Pharmacol., 2017, vol. 331, no. 15, pp. 135-141.

6. Yue Y.C., Li M.H., Wang H.B., Zhang B.L., He W. The toxicological mechanisms and detoxification of depleted uranium exposure. Environ. Health Prev. Med., 2018, vol. 23, no. 1, p. 18.

7. Dinocourt C., Culeux C., Legrand M., Elie C., Lestaevel P. Chronic exposure to uranium from gestation: effects on behavior and neurogenesis in adulthood. Int. J. Environ. Res. Public Health., 2017, vol. 14; no. 5, p. 536.

8. Bjorklund G., Semenova Y., Pivina L., Dadar M., Rahman M.M., Aaseth J., Chirumbolo S. Uranium in drinking water: a public health threat. Arch. Toxicol., 2020, vol. 94, no. 5, pp. 1551-1560.

9. Figgs L.W. Lung cancer mortality among uranium gaseous diffusion plant workers: a cohort study 1952-2004. Int. J. Occup. Environ. Med., 2013, vol. 4, no. 3, pp. 128-140.

10. Asic A., Kurtovic-Kozaric A., Besic L., Mehinovic L., Hasic A., Kozaric M., Hukic M., Marjanovic D. Chemical toxicity and radioactivity of depleted uranium: the evidence from in vivo and in vitro studies. Environ. Res., 2017, vol. 156, pp. 665-673.

11. Bykovchenko Yu.G., Bykova E.I., Belekov T., Tukhvatshin R.R. Technogenic pollution of the biosphere of Kyrgyzstan with uranium. Bishkek, Altyn-Tamga JSC, 2005. 186 p. (In Russian).

12. Kulenbekov Zh.E. Environmental impact assessment study of Kadji-Sai uranium tailing and Issyk-Kul Lake. Dr. gidrogeolog. sci. abstract. Bishkek, 2013. 36 р. (In Russian).

13. Tukhvatshin R.R., Raimzhanov A.R., Isupova A.A., Topchubaeva T.M., Kazieva A.A., Attokurova G.N. Assessment of the impact on human health of environmental factors of uranium tailings. Vestnik kyrgyzsko-rossijskogo slavjanskogo universiteta – Bulletin of the Kyrgyz-Russian Slavic University, 2017, vol. 17, no. 7, pp. 164-167. (In Russian).

14. Elkin V.D., Mitryukovsky L.S., Lysov A.Yu. Prakticheskaja dermatoonkologija: illjustrirovannoe spravochnoe rukovodstvo po opuholjam kozhi, opuholepodobnym zabolevanijam i svjazannymi s nimi sin-dromami [Practical dermato-oncology: an illustrated reference guide to skin tumors, tumor-like disorders, and associated syndromes]. Moscow, Practical medicine, 2014. 480 p.

15. Garg R., Madan S., Prakash P., Chander R., Choudhary M. Leser-Trélat syndrome in a male with breast carcinoma and eyelid basal cell carcinoma. Ocul. Oncol. Pathol., 2018, vol. 4, no. 3, pp. 161-164.

16. Muacevic A., Adler J.R., Lin A.N., Lin K., Kyaw H., Abboud J. A myth still needs to be clarified: a case report of the Frank's sign. Cureus, 2018, vol. 10, no. 1, p. e2080.

17. Nyanti L., Samsudin A., Tiong I.K. Syndrome of inappropriate antidiuretic hormone secretion and Leser-Trélat syndrome as uncommon paraneoplastic manifestations of renal malignancy – a geriatric experi-ence: a case report. J. Med. Case Rep., 2019, vol. 13, no. (1), p. 188.

18. Guastafierro A., Verdura V., Di Pace B., Faenza M., Rubino C. The influence of breast cancer on the distribution of cherry angiomas on the anterior thoracic wall: a case series study. Dermatology, 2019, vol. 235, no. 1, pp. 65-70.

19. Bertell R. X-ray exposure and premature aging. J. Surg. Oncol., 1977, vol. 9, no. 4, pp. 379-391.

20. Ermolaeva M., Neri F., Ori A., Rudolph K.L. Cellular and epigenetic drivers of stem cell aging. Nat. Rev. Mol. Cell Biol., 2018, vol. 19, no. 9, pp. 594-610.

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