Risk of endemic non toxic goiter in Chernobyl liquidators and nuclear industry employees

«Radiation and Risk», 2022, vol. 31, No. 1, pp.83-92

DOI: 10.21870/0131-3878-2022-31-1-83-92

Authors

Tukov A.R. – Head of Lab., C. Sc., Med. Contacts: 46 Zhivopisnaya str., Moscow, Russia, 123182. Tel.: 8(910)4422365; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Shafransky I.L. – Sen. Researcher, C. Sc., Med.
Biryukov A.P. – Head of Dep., MD, Prof.
Prokhorova O.N. – Sen. Researcher
Orlov Yu.V. – Researcher
Kalinina M.V. – Engineer-Researcher. Burnasyan Federal Medical Biophysical Center.
Russian State Research Center − Burnasyan Federal Medical Biophysical Center, Moscow

Abstract

Estimates of radiation risk of non-toxic goiter (ICD 10: E04-E04.9) in Chernobyl liquidators were given from the information database of the Sectoral register of persons exposed to radiation as a result of the Chernobyl accident for 1989-2018. Used dosimetry information contained liquidators radiation doses were measured during their work inside the Chernobyl exclusion zone, and the employees’ occupational radiation dose. The study used information about men − 12663 people, of which 1327 workers have an occupational exposure dose. At the first stage, the excess relative risk per 1 Sv (ROR/Sv) of non-toxic goiter was estimated for four groups depending on age at the time of participation in work in the Chernobyl accident zone. At the second stage of the study, a Poisson process with an intensity parameter was chosen as a statistical model of morbidity. Based on the obtained individual non-stratified data, an analytical likelihood function for the Poisson process was built and the value of the excess relative risk (RRR) of the disease with nontoxic goiter was calculated. The nature of the dose dependence of the IOR was studied, for which the Amfit module of the Epicure statistical software package was used. A cohort study of liquidators 1986-1990 was carried out. for 1989-2018 depending on the dose of external exposure received during the liquidation of the consequences of the Chernobyl accident, and with the total dose received in the 30-km zone of the Chernobyl nuclear power plant with the dose during professional work. The values of the radiogenic risk of non-toxic goiter in liquidators of the consequences of the Chernobyl accident are shown. A significant increase in the risk of IOR disease per dose unit for doses received during the liquidation of the consequences of the Chernobyl accident was not found. A significant increase in risk was noted when using total doses for its calculation only for liquidators in the age group of 50-59 years. The use of doses from various types of exposure in assessing the radiogenic risk of non-toxic goiter in liquidators of the consequences of the Chernobyl accident gives different values of the excess relative risk of developing this nosology. For a correct assessment of the radiation risk of non-toxic goiter, it is nec-essary to collect data on the doses of all types of exposure (occupational, emergency, medical and natural), and only the use of the total dose can give the true risk necessary to calculate the radiation safety standards.

Key words
radiation, relative risk, excess risk, risk of non toxic goiter, study period, Chernobyl accident, EPICURE, ROSATOM, industry register, radiation safety.

References

1. Dedov I.I. Diabetes mellitus is the most dangerous challenge to the world community. Vestnik RAMN – Bulletin of the RAMS, 2012, no. 1, pp. 7-13. (In Russian).

2. Dora S.V., Krasilnikova E.I., Baranova E.I., Grigorieva E.A., Gudieva M.B., Volkova A.R. Changes in the course of Graves' disease in St. Petersburg over the period from 1970 to 2010. Klinicheskaya i eksperimentalnaya tireoidologiya – Clinical and Experimental Thyroidology, 2012, vol. 8, no. 2, pp. 59-63. (In Russian).

3. Andreeva N.S. Improving the organization of medical care for the adult urban population with thyroid pathology. Cand. Med. Sci. Dis. Kursk, 2004. 150 p. (In Russian).

4. Fadeev V.V. Again about the paradigm of treatment of nodular colloid goiter. Klinicheskaya i eksperimentalnaya tireoidologiya – Clinical and Experimental Thyroidology, 2014, vol. 10, no. 4, pp. 61-64. (In Russian).

5. Zhukova L.A., Andreeva N.S., Gulamov A.A., Smirnova A.E. Development of a training program for patients with various thyroid diseases and evaluation of its effectiveness. Vestnik medicinskogo stomatologicheskogo instituta – Bulletin of the Medical Stomatological Institute, 2009, no. 1, pp. 21-23. (In Russian).

6. Zhukova L.A., Timoshchenko E.V., Buryakova Yu.V. Clinical and nosological features of hospitalized patients with thyropathies in a multidisciplinary hospital in Tula (2004-2010). Akademicheskij zhurnal Zapadnoj Sibiri – Academic Journal of Western Siberia, 2012, no. 3, pp. 34-35. [In Russian).

7. Gerasimov G.A. On the WHO recommendations "Fortification of edible salt with iodine for the prevention of diseases caused by iodine deficiency". Klinicheskaya i eksperimentalnaya tireoidologiya – Clinical and Experimental Thyroidology, 2014, vol. 10, no. 4, pp. 5-8. (In Russian).

8. Bahn R.S., Burch H.B., Cooper D.S., Garber J.R., Greenlee M.C., Klein I., Laurberg P., McDougall I.R., Montori V.M., Rivkees S.A., Ross D.S., Sosa J.A., Stan M.N. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Endocrine Practice, 2011, vol. 17, no. 3, pp. 456-520.

9. Babenko A.Yu., Grineva E.N., Solntsev V.N. Atrial fibrillation in thyrotoxicosis – determinants of development and preservation. Klinicheskaya i eksperimentalnaya tireoidologiya – Clinical and Experimental Thyroidology, 2013, vol. 9, no. 1, pp. 29-37. (In Russian).

10. Sheu J.J., Kang J.H., Lin H.C., Lin H.C. Hyperthyroidism and risk of ischemic stroke in young adults: a 5-year follow-up study. Stroke, 2010, vol. 41, no. 5, pp. 961-966.

11. Siu C.W., Yeung C.Y., Lau C.P., Kung A.W., Tse H.F. Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism. Heart, 2007, vol. 93, no. 4, pp. 483-487.

12. Pishchugina A.V., Ivanov A.G., Belyakova N.A. Peculiarities of morbidity of workers at a nuclear power plant. Problemy social'noj gigieny, zdravookhraneniya i istorii meditsiny – Problems of Social Hygiene, Health Care and the History of Medicine, 2013, no. 1, pp. 18-21. (In Russian).

13. Ivanov V.K., Tsyb A.F., Maksioutov M.A., Gorski A.I., Marchenko T.A., Kaidalov O.V., Korelo A.M., Chekin S.Yu., Petrov A.V., Biryukov A.P., Kochergina E.V., Kruglova Z.G., Zelenskaya N.S., Vlasov O.K., Shchukina N.V., Kashcheeva P.V., Tumanov K.A., Mikhalsky A.I. The main results of the radiation-epidemiological analysis of the data of the RGMDR (for the 20th anniversary of Chernobyl). Radiatsiya i risk – Radiation and Risk, 2005, special issue 3, pp. 6-111. (In Russian).

14. Galstyan I.A., Guskova A.K., Nadejina N.M. Consequences of radiation exposure resulted from Chernobyl Nuclear Plant accident: analysis of clinical data. Meditsinskaya radiologiya i radiatsionnaya bezopasnost' – Medical Radiology and Radiation Safety, 2007, vol. 52, no 4, pp. 5-13. (In Russian).

15. Breslow N.E., Day N.E. Statistical Methods in Cancer Research. Vol. I. The analysis of case-control studies. IARC Scientific Publication No. 32. Lyon, IARC, 1980. 350 p.

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