The links between solar activity and smoke with trends in hematological malignancies in Russia

«Radiation and Risk», 2022, vol. 31, No. 3, pp.100-110

DOI: 10.21870/0131-3878-2022-31-3-100-110

Authors

Pinaev S.K. – Assistant Prof., C. Sc., Med. Contacts: 35, Muravyova-Amuskogo str., Khabarovsk, 680000, Russia; Tel.: +79145440220; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Pinaeva O.G.– Assistant Prof., C. Sc., Med. FESMU.
Chizhov A.Ya. – Prof. of SRC – FMBC, MD, Honored Scientist of RF, Academician of the REA, Consultant Prof. of RUDN University.
¹ Far-East State Medical University, Khabarovsk
² State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow
³ Peoples' Friendship University of Russia, Moscow

Abstract

Hematological malignancies, which include leukemia, Hodgkin's lymphoma (HL), non-Hodgkin's lym-phomas (NHL) and multiple myeloma, amount 6.6% of the global incidence of malignant neoplasms, and 4.7% in Russia. A significant number of studies indicate the involvement of environmental factors in the occurrence of hematological malignancies. The role of electromagnetic waves in the origin of NHL is indicated by data on the increased risk of developing them in occupations associated with electricity. Leukemia in children is positively associated with vehicle smoke. There are indications of a role in the emergence of HL of tobacco smoke. Previously, the authors established a links between the incidence of NHL and leukemia in cohorts of young children with the activity of the Sun, and in leukemia a correlation with the smoke of forest fires was also found. In this work has been investi-gated the relations between the trends in the incidence of hematological malignancies in the popula-tion of Russia in 1993-2018 with smoke and solar activity. There was a tendency towards an increase in the incidence of hematological malignancies (p<0.001) by 2.8% per year. The incidence of leuke-mia (p=0.004), NHL (p<0.001), and multiple myeloma (p<0.001) significantly increased. This trend is presumably related to the increase in the number of cars in the country. The incidence of HL, on the contrary, is characterized by a downward trend (p=0.019). A link was found between the activity of the Sun and the incidence of leukemia (r=0.708, p=0.010, lag 2 years), NHL (r=0.689, p=0.013, lag 2 years), multiple myeloma (r=0.657, p=0.020, lag 2 years) and LH (r=0.606, p=0.037, lag 7 years). The data obtained suggest a significant contribution of smoke and solar activity to the occurrence of hematological malignancies in children and adults. Based on the role of environmentally related oxi-dative stress in oncogenesis, it is recommended for the prevention of hematological malignancies to consume a sufficient amount of vitamins, regularly include in the diet fresh vegetables, fruits, foods to stimulate autophagy and Transfer Factor.

Key words
solar radiation, ecology, environmental factors, smoke, hematological malignancies, leukemia, lymphogranulomatosis, Hodgkin's lymphoma, multiple myeloma, non-Hodgkin's lymphomas.

References

1. International Agency for Research on Cancer. Available at: https://iarc.fr/ (Accessed 01.07.2021).

2. Malignant neoplasms in Russia. Available at: http://www.oncology.ru/service/statistics/malignant_tumors/ (Accessed 01.07.2021). (In Russian).

3. Karipidis K., Benke G., Sim M., Fritschi L., Yost M., Armstrong B., Hughes A.M., Grulich A., Vajdic C.M., Kaldor J., Kricker A. Occupational exposure to power frequency magnetic fields and risk of non-Hodgkin lymphoma. Occup. Environ. Med., 2007, vol. 64, no. 1, pp. 25-29. DOI: 10.1136/oem.2005.022848.

4. Villeneuve P.J., Agnew D.A., Miller A.B., Corey P.N. Non-Hodgkin's lymphoma among electric utility work-ers in Ontario: the evaluation of alternate indices of exposure to 60 Hz electric and magnetic fields. Occup. Environ. Med., 2000, vol. 57, no. 4, pp. 249-257. DOI: 10.1136/oem.57.4.249.

5. Boothe V.L., Boehmer T.K., Wendel A.M., Yip F.Y. Residential traffic exposure and childhood leukemia: a systematic review and meta-analysis. Am. J. Prev. Med., 2014, vol. 46, no. 4, pp. 413-422. DOI: 10.1016/j.amepre.2013.11.004.

6. Whitehead T.P., Metayer C., Wiemels J.L., Singer A.W., Miller M.D. Childhood leukemia and primary prevention. Curr. Probl. Pediatr. Adolesc. Health Care, 2016, vol. 46, no. 10, pp. 317-352. DOI: 10.1016/j.cppeds.2016.08.004.

7. Jin M.W., Xu S.M., An Q., Wang P. A review of risk factors for childhood leukemia. Eur. Rev. Med. Pharmacol. Sci., 2016, vol. 20, no. 18, pp. 3760-3764. Available at: https://www.europeanreview.org/arti-cle/11444 (Accessed 01.07.2021).

8. Hjalgrim H., Ekström-Smedby K., Rostgaard K., Amini R.M., Molin D., Hamilton-Dutoit S., Schöllkopf C., Chang E.T., Ralfkiaer E., Adami H.O., Glimelius B., Melbye M. Cigarette smoking and risk of Hodgkin lymphoma: a population-based case-control study. Cancer Epidemiol. Biomarkers Prev., 2007, vol. 16, no. 8, pp. 1561-1566. DOI: 10.1158/1055-9965.EPI-07-0094.

9. Kamper-Jørgensen M., Rostgaard K., Glaser S.L., Zahm S.H., Cozen W., Smedby K.E., Sanjosé S., Chang E.T., Zheng T., La Vecchia C., Serraino D., Monnereau A., Kane E.V., Miligi L., Vineis P., Spinelli J.J., McLaughlin J.R., Pahwa P., Dosman J.A., Vornanen M., Foretova L., Maynadie M., Staines A., Becker N., Nieters A., Brennan P., Boffetta P., Cocco P., Hjalgrim H. Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph). Ann. Oncol., 2013, vol. 24, no. 9, pp. 2245-2255. DOI: 10.1093/annonc/mdt218.

10. Cancer in adolescents and young adults: pediatric oncology. Eds.: A. Bleyer, R. Barr, L. Ries, J. Whelan, A. Ferrari. Second Edition, Library of Congress Control Number: 2016951645. Springer International Publishing AG, 2017. 825 p. DOI: 10.1007/978-3-319-33679-4.

11. Pinaev S.K., Pinaeva O.G., Chizhov A.Ya. About the role of environmental factors in carcinogenesis. Actual Problems of Ecology and Environmental Management: Cooperation for Sustainable Development and Environmental Safety (APEEM 2020), E3S Web Conf., 2020, vol. 169, pp. 04003. DOI: 10.1051/e3sconf/202016904003.

12. Chizhov A.Ya., Pinaev S.K. Effects of solar radiation and woodsmoke on risk of childhood leukaemia: system analysis. Radiatsiya i risk – Radiation and Risk, 2018, vol. 27, no. 4, pp. 87-94. DOI: 10.21870/0131-3878-2018-27-4-87-94. (In Russian).

13. Pinaev S.K., Chizhov A.Ya., Pinaeva O.G. Critical periods of adaptation to oncogenic environmental factors at the stages of ontogenesis. Actual Problems of Ecology and Environmental Management (APEEM 2021), E3S Web Conf., 2021, vol. 265, pp. 06006. DOI: 10.1051/e3sconf/202126506006.

14. Pinaev S.K., Chizhov A.Ya. Environmentally related oxidative stress in oncogenesis in children. Advances in Molecular Oncology: materials of the 5th All-Russian conference on molecular oncology, 16-18 December 2019, Moscow, 2019, vol. 6, no. 4 (Suppl.), pp. 73. Available at: https://umo.abvpress.ru/jour/arti-cle/view/245/195 (Accessed 01.07.2021). (In Russian).

15. Federal State Statistics Service. Transport in Russia. Available at: https://rosstat.gov.ru/ (Accessed 01.07.2021). (In Russian).

16. SILSO data/image, Royal Observatory of Belgium, Brussels. Available at: http://www.sidc.be/silso/datafiles (Accessed 01.07.2021).

17. IARC monographs on the identification of carcinogenic hazard to humans. Agents Classified by the IARC Monographs, Volumes 1-127. Available at: https://monographs.iarc.fr/list-of-classifications (Accessed 01.07.2021).

18. Pinaev S.K., Chizhov A.Ya. System analysis of the influence of solar radiation and smoke from forest fires on the risk of developing malignant neoplasms in children. Advances in molecular oncology: materials of the IV All-Russian Conference with International Participation on Molecular Oncology, 17-19 December 2018, Moscow, 2018, vol. 5, no. 4 (Suppl.), pp. 9. Available at: https://umo.abvpress.ru/jour/article/view/187/167 (Accessed 01.07.2021). (In Russian).

19. Chizhov A.Ya., Pinaev S.K., Savin S.Z. Environmentally-related oxidative stress as a carcinogenesis factor. Tekhnologii zhivykh system – Technologies of living systems, 2012, vol. 9, no. 1, pp. 47-53. Available at: https://elibrary.ru/item.asp?id=17741394 (Accessed 01.07.2021). (In Russian).

20. Pinaev S.K., Pinaeva O.G., Chizhov A.Ya. Environmentally-induced alternative oncogenesis: EROS arrows. Actual Problems of Ecology and Environmental Management: Cooperation for Sustainable Development and Environmental Safety (APEEM 2020), E3S Web Conf., 2020, vol. 169, pp. 04006. DOI: 10.1051/e3sconf/202016904006.

21. Zenkov N.K., Chehushkov A.V., Kozhin P.M., Martinovich G.G., Kandalintseva N.V., Menshchikova E.B. Autophagy as a protective mechanism in oxidative stress. Byulleten' Sibirskoy meditsiny – Bulletin of Siberian Medicine, 2019, vol. 18, no. 2, pp. 195-214. DOI: 10.20538/1682-0363-2019-2-195-214. (In Russian).

22. Davydov V.V., Bozhkov A.I. Carbonyl stress is a nonspecific factor of pathogenesis. ZHurnal NAMN Ukraїn – Journal of the National Academy of Medical Sciences of Ukraine, 2014, vol. 20, no. 1, pp. 25-34. Available at: https://iozdp.org.ua/files/davydov_namn_2014.pdf (Accessed 01.07.2021). (In Russian).

23. Senger D.R., Li D., Jaminet S.C., Cao S. Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern western diet. PLoS One, 2016, vol. 11, no. 2. DOI: 10.1371/journal.pone.0148042.

24. Filomeni G., De Zio D., Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ., 2015, vol. 22, no. 3, pp. 377-388. DOI: 10.1038/cdd.2014.150.

25. Viza D., Fudenberg H.H., Palareti A., Ablashi D., De Vinci C., Pizza G. Transfer factor: an overlooked potential for the prevention and treatment of infectious diseases. Folia Biol. (Praha), 2013, vol. 59, no. 2, pp. 53-67. Available at: https://fb.cuni.cz/volume-59-2013-no-2#articFB2013A0007 (Accessed 01.07.2021).

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